![]() ![]() Low-grade spindle cell sarcomas located at or distal to the elbow and stifle joints can be excised without need for wide or radical surgery. Marginal surgical excision without adjuvant treatment of low-grade soft tissue spindle cell sarcoma of the extremities results in a low local recurrence rate. The sarcomas may be smaller or larger, mostly solid, but there are a few tumors that may be filled with fluid. There were no significant differences among survival functions stratified by histologic margins. What is spindle cell cancer in dogs Spindle cell sarcomas are also known as soft tissue sarcomas (STS) and in general, this term acts as an umbrella for a variety of tumors including (fibrosarcoma-connective tissue, chondrosarcoma-cartilage, liposarcoma-fat tissue, hemangiosarcoma-blood vessel cells, nerve sheath tumor, hemangiopericytoma. The spindle cell sarcomas may be felt as lumps under the dog’s skin. If removal is incomplete or not possible, adjunct radiation therapy can be pursued. If surgery is possible, wide-surgical excision is pursued. Routine staging is recommended to help dictate therapy. These tumors can arise anywhere there is soft tissue, including the limbs, joints, face, intestine and reproductive tissues. Median DFI and survival time were not reached, because <50% of dogs died of disease-related events. Soft tissue sarcomas are a broad category of tumor types. Local recurrence and metastatic rates were 10.8% and 0%, respectively. Follow-up after surgery occurred from 210 to 2202 days (minimum, 180 days). Sarcoma in dogs is a cancerous, malignant tumor or growth that can appear on the skin or inside the dog. Histopathologic margins were dirty (12 dogs), clean but close (12), and clean (11). Medical records were reviewed and dogs that had marginal surgical resection of low-grade soft tissue spindle cell sarcoma at or distal to elbow and stifle were included. Further studies are needed to document the biological behavior of these tumors in dogs.Ĭanine histochemistry immunohistochemistry lipoma soft tissue sarcoma spindle cell lipoma.To evaluate recurrence rate and disease-free interval (DFI) of dogs with low-grade soft tissue spindle cell sarcoma of the extremities treated by marginal excision.ĭogs (n=35) with soft tissue low-grade spindle cell sarcoma. Awareness of SCL and its specific histopathological features is essential to diagnose this specific tumor. Soft-tissue sarcomas (STS) are common for a practitioner to see as they compromise up to 15 percent of all skin tumors in dogs. Neoplastic cells were immunohistochemically positive for vimentin and negative for S100 protein, smooth muscle actin, factor VIII-ra, and MDM2. Average mitotic count in 10 high-power fields was 0.17. Mature adipocytes represented less than 10% of the neoplasm in 3 cases and were absent in the remaining 3. Sudan IV stain performed in 1 case demonstrated the lipid content of vacuoles. All SCLs were located in the subcutis and were composed of bland, occasionally vacuolated spindle cells intermixed with ropey collagen and myxoid matrix. For average-sized grade 1 and 2 soft tissue sarcomas, treated with surgery and possibly radiation therapy, approximately three-quarters of patients will be. This report describes the histopathological features of 6 SCLs in dogs. Spindle cell lipoma (SCL) is a benign neoplasm of the adipose tissue that may resemble an undifferentiated soft tissue sarcoma (STS). ![]()
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